Overview

Eligibility

Design Details

Arms & Interventions

Outcome Measures

Trial Sites

Source: ACTRN12621001232820

Recruiting

Siemens WIP: Use of Siemens prototype sequences for Magnetic Resonance Imaging in radiation oncology

Interventional

Phase not listed

Investigative Site

Sponsor: South Western Sydney Local Health District

Last Updated: June 21, 2025

Notice- Information is sourced from public registries and may not reflect real-time changes at the local site.

This study aims to investigate the use of newly developed magnetic resonance imaging (MRI) prototype sequences (different settings on the MRI scanner that results in different image appearances) to be used in parallel with standard MRI sequences to compare the usability and potential benefits for cancer patients undergoing radiotherapy treatment.

Who is it for?
You may be eligible for this study if you are aged 18 years or older, have been diagnosed with any type of cancer and you are receiving radiotherapy that requires a MRI scan for radiotherapy treatment planning purposes.

Study details
Participants who agree to enroll in this study will be asked to undergo additional MRI sequence(s) on top of the standard MRI sequences that are part of their regular radiotherapy treatment. Your doctor will review and discuss with you whether additional MRI sequence(s) will be of benefit to the planning of your radiotherapy treatment. If this is the case a maximum of 15minutes may be added to your standard radiotherapy planning MRI scan to allow these sequences to be obtained.

It is hoped this research will allow engineers to further refine and design more specialised MRI sequences that will allow clinicians to improve personalised care for cancer patients who are undergoing radiotherapy.

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Treatment Category

Required Mutations

None

Trial Started

September 30, 2021

Last Updated by Sponsor

June 21, 2025

Estimated Completion

No date listed

Contact Study

Name:Ms Radiation Oncology Clinical Trials team

Email:SWSLHD-RadOncClinicalTrials@health.nsw.gov.au

Phone:+61 429094402

Name:A/Prof Lois Holloway

Email:Lois.Holloway@health.nsw.gov.au

Phone:+61 429094402

Eligibility

Inclusion Criteria

Any patient receiving radiotherapy that requires MRI for radiotherapy treatment planning purposes.

Exclusion Criteria

- Any contraindication to MRI

- Age <18years

- Patient refusal

- Inability to provide informed consent

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Design Details

AllocationNon-randomised trial

Intervention ModelSingle group

MaskingOpen (masking not used)

Number to Enroll250

Arms & Interventions

Arms

Interventions

No interventions available.

Outcome Measures

Primary Outcome Measures

After the MRI scan (standard + prototype sequences) is taken.

Composite image quality analysis of prototype sequences by assessing the contrast, noise and artefacts using image analysis software and visual assessment by the end user

After all participants complete their scans.

Feasibility of implementing prototype sequences in standard practice as assessed by extra time requirements by review of scan time of prototype sequence(s) as recorded on scanner by MRI technician.

After all participants complete their scans.

Feasibility of implementing prototype sequences in standard practice by a composite assessment of usefulness for treatment volume delineation and dosimetry plan as assessed by study survey of Radiation Oncologists and Radiation Therapists.

Secondary Outcome Measures

Patient satisfaction with prototype MRI process sequence(s) in addition to standard radiotherapy planning MRI as assessed by documenting any concerns or discomfort at the time of scanning and feed back to study investigator.After the MRI scan (standard + prototype sequences) is taken.

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Trial Sites

This study has 2 trial sites

Investigative Site

City of Campbelltown, New South Wales, AU

Recruiting

City of Campbelltown, New South Wales, 2560 AU

Investigative Site

Recruiting

Liverpool City Council, New South Wales, 2170 AU

Investigative Site

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