COBRA: Cancer, Older Adults, Balance and Resistance Activities
Interventional
Phase not listed
Memorial Sloan Kettering Monmouth (Consent only)
The purpose of this study is to find out whether an 8-week digital health promotion program called COBRA is a safe and practical (feasible) option for older adults with cancer/OAC.
Treatment Category
Behavioral
Required Mutations
None
Trial Started
2025-05-30
Last Updated by Sponsor
2025-06-10
Estimated Completion
2027-05-30
Eligibility
Inclusion Criteria
Older Adult Patients with Cancer
- Are within 1 year of completion of primary therapy for cancer OR have a diagnosis of metastatic cancer;
1. For the purpose of this study, primary therapy is defined as treatment of curative intent, first-line or later, from which the individual is advancing to active surveillance or follow-up with or without maintenance therapy.
2. Individuals with metastatic cancer may be included provided they have stable disease or better per most recent restaging exam at time of enrollment.
i. Patients with stable metastatic bony disease at most recent restaging exam and a score of 0-2 on the Functional Pain Scale (FPS69; Appendix 18) are eligible. The PI will consult with the Rehab Med co-PI for FPS scores of 3 or greater, by patient request or PI discretion.
ii. Patients with symptomatic visceral metastases will be evaluated on a case-by-case basis at time of enrollment.
* Are aged 65 years and older, with no upper age limit;
* ECOG PS 0-3 or Karnofsky PS greater than or equal to 40;
* Can read and speak English;
* Self-report access to internet connection sufficient to support videoconferencing.
Clinicians
* Licensed clinician (MD, RN, APP) with an interest in the care of older adults with cancer.
Exclusion Criteria
Older Adult Patients with Cancer
* Have any cognitive impairment, neurologic, musculoskeletal, or other comorbid condition (as assessed by their provider) that would prevent the individual from engaging with the digital health coaching program or complete study assessments or engage in progressive intensity levels of physical activity
* Have a neurologic, musculoskeletal, or other comorbid condition that would impede their ability to safely engage in progressive intensity levels of physical activity (as assessed by their provider). Patients with metastatic disease and suspected interim progression since last restaging exam will be referred back to their primary oncology care team for evaluation prior to enrollment.
* Have activity restrictions post-surgery at the time of enrollment
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Design Details
AllocationN/A
Intervention ModelSingle Group Assignment
MaskingNone (Open Label)
Number to Enroll38
Arms & Interventions
Arms
Interventions
Type: Experimental
Description: Older Adult Patients with Cancer are within 1 year of completion of primary therapy for cancer OR have a diagnosis of metastatic cancer;
Interventions:
Cancer, Older adults, Balance and Resistance Activities
Outcome Measures
Primary Outcome Measures
Rate of retention and adherence to the COBRA/Cancer, Older Adults, Balance and Resistance Activities intervention8 weeks
Rate of retention and adherence to the 8-week intervention to define intervention feasibility
Secondary Outcome Measures
None
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Trial Sites
This study has 6 trial sites
Memorial Sloan Kettering Monmouth (Consent only) Middletown, New Jersey, US
Recruiting
Middletown, New Jersey, 07748 US
Memorial Sloan Kettering Monmouth (Consent only)
Recruiting
Harrison, New York, 10604 US
Memorial Sloan Kettering Westchester (Consent only)
Recruiting
Montvale, New Jersey, 07645 US
Memorial Sloan Kettering Bergen (Consent Only)
Recruiting
Uniondale, New York, 11553 US
Memorial Sloan Kettering Nassau (Consent Only)
Recruiting
New York, New York, 10065 US
Memorial Sloan Kettering Cancer Center (All Protocol Activites)
Recruiting
Commack, New York, 11725 US
Memorial Sloan Kettering Suffolk-Commack (Consent Only)