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It is defined as the percentage of patients achieving complete response (CR), partial response (PR), or stable disease (SD) for 16 weeks or longer.
It is defined as the time from the first dose to disease progression or death on study from any cause, whichever occurs first in patients who achieve CR, PR or SD for 16 weeks or longer.
Overall Response is defined as sum of CR and PR.
It is defined as the time from the first dose to disease progression or death on study from any cause, whichever occurs first.
Number of adverse events reported by the patients
plasma concentrations of drug
Baseline mutational status and its correlation with efficacy